15346 – A microneedle delivery platform that can be used to safely and painlessly inject a combination of drugs, such as plasmid DNA-encoding antigens and adjuvants, can be used in a variety of therapeutic settings. Microneedle arrays have been employed as an alternative approach to traditional needles because they are safer, more convenient, and pain-free. Upon contact with the skin, they... Read More
17193 – This invention is a novel combinatorial therapy design for cancer treatment. Though the number of approved cancer therapies has risen dramatically over the past decade, it has become apparent that the efficacy of a single treatment is limited. Combinatorial therapy has become increasingly important, especially in the field of immunotherapy, where engaging multiple responses... Read More
16631 – This invention is an RNA-based genetic circuit which can produce antigens or numerous proteins including: therapeutic, cell death, fluorescent, and selection proteins. This technology may be used for a number of applications including, but not limited to, selective stem cell reprogramming or vaccination.
18577 – This technology increases the potency of cancer vaccines. There is only one FDA approved cancer vaccine, Sipuleucel-T, which only provides a modest survival benefit from prostate cancer. Sipuleucel-T depends on the manipulation of a patient’s own immune cells, and therefore suffers from logistical difficulties that create barriers to its widespread adaptation. Conversely, more... Read More
17500 – Applications for this technology are found in the storage and transportation of pharmaceuticals, i.e., vaccines. Pharmaceutical substances must be kept under strict temperature control in order to prevent any negative effects that can occur when they are exposed to temperatures above or below the recommended range. Vaccines, especially, lose potency when exposed to temperatures... Read More
15365 – Monitoring environmental pollution, detection of biomarkers in biological samples and tracking food pathogens require simultaneous identification of multiple of analytes. In developing markets, low cost robust assays of adequate sensitivity and specificity are not available. This work presents a compact point-of-care sensor platform capable of simultaneous detection of multiple... Read More