16631 – This invention is an RNA-based genetic circuit which can produce antigens or numerous proteins including: therapeutic, cell death, fluorescent, and selection proteins. This technology may be used for a number of applications including, but not limited to, selective stem cell reprogramming or vaccination.
18076 – This invention reduces dosages and improves efficacy of RNA interference drugs including cancer therapeutics. Short interfering RNAs (siRNAs) have great therapeutic potential but clinical translation has been hindered by poor in vivo stability, low loading efficiency, and dose-limiting toxicity. The generation of periodic short hairpin RNA (concatemeric siRNA) via rolling circle... Read More
16876 – The generation of robust, scalable gene networks that interfere minimally with endogenous cellular processes is fundamental to synthetic biology. The use of RNA regulatory strategies in combination with CRISPR/Cas transcription factors (CRISPR-TFs) allows for the conditional regulation of large-scale synthetic and endogenous gene networks in eukaryotic cells. The system is uniquely... Read More