Utilization of Cyclodextrins for Drug Delivery from Degradable Layer-By-Layer Films

Technology #12978

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Categories
Inventors
Professor Paula Hammond
Department of Chemical Engineering, MIT
External Link (hammondlab.mit.edu)
Renee Smith
Program of Health Sciences and Technology, MIT
Managed By
Jon Gilbert
MIT Technology Licensing Officer
Patent Protection

Controlled delivery of bioactive agents from decomposable films

US Patent 9,198,875

Applications

This invention allows for improved Layer-by-Layer films for therapeutic coatings on medical implants or controlled release in systemic delivery. The technology may also be used in a number of food, cosmetic, or household applications such as food-flavoring agents, air fresheners, or pheromone-based moth traps.

Problem Addressed

Patients with prosthetic implants incur a high risk of postoperative complications such as inflammation and infection. Combination devices that provide local, sustained release of therapeutic drugs reduce the risk of complications and do not require patients to follow a post-surgical drug regimen. Currently, most coated implants have limited utility since harsh processing conditions allow only a single drug, able to withstand fabrication, to be incorporated into these devices. Furthermore, there is an inability to engineer drug release. Layer-by-Layer (LbL) films have the potential to offer low cost, versatile, and controlled drug release. This invention is a method to deliver small hydrophobic molecules using LbL films.

Technology

LbL films are formed by the adsorption of oppositely charged polyelectrolytes on substrates and can be only nms thick. This invention uses Cyclodextrins, toroidally shaped oligosaccharides that can be constituted by six to eight glucopyranose units, as a carrier for small hydrophobic molecules. Controlled release of these molecules has been confirmed through monitoring the incorporation and release of ciprofloxacin, dexamethasone, and prodan. This degradable, multilayer system not only allows flexibility to coat objects of any size, shape or surface chemistry, but also encourages the incorporation of multiple drugs.

Advantages

  • Low cost and applicable to a broad set of drugs
  • Controlled release of one or more drugs¬†
  • Degradable, nanoscale coating for objects of any size, shape or surface chemistry