Continuous Release of Cisplatin for Treatment of Ovarian Cancer

Technology #15385

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Inventors
Professor Michael Cima
Department of Material Science and Engineering, MIT
External Link (web.mit.edu)
Hongye Ye
Harvard-MIT Division of Health Sciences and Technology, MIT
Marcela del Carmen
Massachusetts General Hospital
Michael Birrer
Massachusetts General Hospital
Managed By
Ben Rockney
MIT Technology Licensing Officer
Patent Protection

Medicament, method, and drug delivery device for treatment of ovarian cancer

US Patent Pending 2015-0080847

Medicament, method, and drug delivery device for treatment of ovarian cancer

PCT Patent Application Filed

Applications

  • Intraperitoneal chemotherapy for ovarian cancer

Problem Addressed

Current standard treatment for advanced ovarian cancer entails cytoreduction surgery to remove the bulk of tumor, followed by intravenous (IV) or intraperitoneal (IP) chemotherapy with a platinum based agent such as cisplatin.  Direct IP administration of cisplatin into the peritoneal cavity reaches much higher level of drug concentration compared to IV systemic delivery; however, more than half of the patients drop out of IP chemotherapy regimen mainly because of catheter related complications.  The incidence of catheter-related complications has limited the utilization of IP chemotherapy.

Technology

This invention pertains to an implantable intraperitoneal drug delivery device for the treatment of ovarian cancer.  This device can be implanted and removed from the peritoneal cavity through minimally invasive laparoscopic surgery.  This approach eliminates catheter-related complications.  This reservoir based device works by allowing peritoneal fluid to enter the device and dissolve the powdered drug, and releasing the drug in solution.  Because the drug is in solid form within the device, the device is much smaller than would be the case if it were in solution.  In addition, the stability of solid cisplatin is superior over cisplatin solution, which allows for maximum drug efficacy upon release even months after implantation.

Advantages

  • No catheter; completely eliminates catheter-related complications
  • Implantable and removable via minimally invasive laparoscopic surgery
  • Superior drug stability
  • Maximum and long lasting drug efficacy