Integrated System for Measuring Leukocyte Activation

Technology #16736

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Inventors
Professor Joel Voldman
Department of Electrical Engineering and Computer Science, MIT
External Link (www.rle.mit.edu)
Hao-Wei Su
Department of Electrical Engineering and Computer Science, MIT
External Link (www.rle.mit.edu)
Javier Prieto
Department of Electrical Engineering and Computer Science, MIT
External Link (www.rle.mit.edu)
Professor Jongyoon Han
Departments of Biological Engineering and Electrical Engineering and Computer Science, MIT
External Link (www.rle.mit.edu)
Lidan Wu
Department of Biological Engineering, MIT
External Link (www.rle.mit.edu)
Managed By
Michelle Hunt
MIT Technology Licensing Officer
Patent Protection

Integrated Electrical Profiling System for Measuring Leukocytes Activation from Whole Blood

US Patent Pending US 2016-0331297

Applications

This tool can be used for sepsis detection and diagnosis in a hospital setting, asa prognostic indicator of an autoimmune episode or neutropenia, and as a point of care monitoring system.

Problem Addressed

Sepsis is a condition characterized by uncontrolled inflammation resulting from a microbial infection, most often in a hospital setting.  In the United States, close to one million incidences of sepsis occur yearly, with a morbidity of 40-60%, incurring an estimated $400 million in treatment costs.  Early and accurate diagnosis of the condition is essential for effective treatment, and current diagnosis options are limited.  

Technology

Professors Jay Han and Joel Voldman have developed a technology to address this issue.  Their novel detection system allows for isolation and quantification of activated neutrophils, which have been established as a biomarker of sepsis.  Requiring only a small sample volume and a relatively rapid assay time, this device can be used to monitor the onset and progression of sepsis in a sensitive and specific manner.  Moreover, this system can be adapted to monitor a range of conditions associated with elevated levels of inflammation, such as autoimmune diseases, and in both clinical and non-clinical settings.

Advantages

  • Small sample volume
  • Rapid assay time
  • High sensitivity and specificity
  • Label free 
  • Can be performed in an outpatient setting