Automated high-throughput screening of biologics, toxins, drug delivery vehicles, or environmental factors in small animals
In vivo animal studies are an essential part of the preclinical phase of the drug discovery process. Currently, there are no means for high-throughput characterization of biologics using in vivo animal models.
The technology presented here provides a large-scale in vivo assessment platform that controls delivery of a drug to desired organs of a group of animals to enable high-throughput in vivo screening. The platform enables parallel and automated manipulation of a group of zebrafish larvae for drug injection and subsequent screening.
The setup consists of a microfluidic system that first embeds animals in gel droplets, positions them on a screening plate, and later injects a drug at a specific time, location, and depth into a target organ with assistance from a computer vision algorithm.
High-throughput injection and screening process
Precise control over the injection process (position, depth, time)
Automated handling of an animal during entire screen
Possibility to work with a number of small vertebrates