Photoexcitation of Intermediates to Accelerate Photocatalyst Regeneration and Increase its Efficiency

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Mechanism of light-assisted Eosin Y photocatalyst regeneration.
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Inventors
Professor Hadley Sikes Johnson
Department of Chemical Engineering, MIT
External Link (hsikeslab.mit.edu)
Alan Aguirre
Department of Chemical Engineering, MIT
Managed By
Jon Gilbert
MIT Technology Licensing Officer
Patent Protection

Photoexcitation of Intermediates to Accelerate Photocatalyst Regeneration and Increase its Efficiency

Provisional Patent Application Filed
Publications
A Quantitative Analysis of Peroxy-Mediated Cyclic Regeneration of Eosin Under Oxygen-RichPhotopolymerization Conditions
Polymer, July 9, 2015, p. 169-177
UV-Vis/FT-NIR in situ Monitoring of Visible-Light Induced Polymerization of PEGDA Hydrogels Initiated by Eosin/Triethanolamine/O2
Polymer Chemistry, January 21, 2016, p. 592-602

Applications

A novel photocatalyst to counter oxygen inhibition in the polymerization and crosslinking reactions initiated by radicals could be used in the synthesis of hydrogels in biomedicine, where oxygen must always be present.

Problem Addressed

Polymerization and crosslinking reactions are widely used in the synthesis of hydrogels in biomedicine. However, oxygen present in physiological conditions inhibits these reactions by oxidizing the reagents. A novel regenerating photocatalyst that could react with oxygen upon photostimulation would prevent oxygen from inhibiting the reaction in such a manner.

Technology 

This invention comprises a photocatalyst, Eosin Y, which acts aqueously during the radical polymerization of hydrogel precursor polyethylene glycol dicacrylate (PEGDA) to confer resilience to oxygen inhibition. In general, photocatalysts are substances that absorb light to increase the speed of a reaction, and are able to regenerate anew for each round of reactions. Eosin Y, in particular, interacts with triethanolamine (TEOA) in a reaction cycle that is driven by two separate wavelengths of light applied at two different times during the reaction cycle. These wavelengths ensure a higher rate of catalyst regeneration and thus reduce Eosin Y “death,” or inhibition, over multiple cycles. In each reaction cycle, Eosin Y interacts with oxygen molecules to prevent them from inhibiting the polymerization of PEGDA. This mechanism, as well as the optimum wavelengths for photocatalysis, were verified with spectroscopic data. Based on these data, hundreds of O2 molecules are consumed per photon absorbed.

Advantages

  • Novel photocatalyst used in the synthesis of hydrogels for biomedical purposes
  • Increased efficiency of photocatalyst regeneration by two particular wavelengths of light
  • Reduction of oxygen inhibiton in hydrogel formation