Heterogeneous Organic Gel Catalyst for Photo-Controlled Chemistry

Technology #19049

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Synthesis of the Gel-PTH Gel-PTH catalyst enables external control of photo-CRP from TTC-1 in organic solvent. (A) light “ON”/“OFF” controlled polymerization of NIPAAM in MeCN; (B) catalyst “IN”/“OUT” controlled polymerization of NIPAAM in MeCN; (C) Reaction time vs ln([M]0/[M]t), with [M]0 and [M]t being the concentration of monomers at time points 0 and t, respectively; (D) % conversion vs Mn and % conversion vs Mw/Mn.“AND” Logic-CRP enabled by Gel-PTH catalyst. (A) Light “ON”/“OFF” and catalyst “IN”/“OUT” controlled polymerization; (B) Reaction time vs ln([M]0/[M]t), with [M]0 and [M]t being the concentration of monomers at time points 0 and t, respectively; (C) % conversion vs Mn and % conversion vs Mw/Mn.(A) Temperature “LOW”/“HIGH” controlled polymerization of NIPAAM in aqueous media; (B) “AND” Logic-CRP with Light “ON”/“OFF” and Temperature “LOW”/“HIGH” enabled by Gel-PTH catalyst.a) Reaction conditions: monomer (1.5 M), the molar ratio of monomer/iniferter/PTH was as shown in the table, room temperature, a 14 W CFL bulb was used for irradiation. Mn = number-average molar mass; Mw = weight-average molar mass. The conversion of monomer was determined by 1H NMR spectroscopy. Mn,theory was calculated according to the monomer conversion. Mn,GPC and Mw/Mn were determined by GPC analysis. b) The molar ratio of catalyst is calculated according to the PTH unit content contained in the Gel-PTH added into the reaction. cLED (λmax = 410 nm) light is used.
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Inventors
Professor Jeremiah Johnson
Department of Chemistry, MIT
External Link (web.mit.edu)
Mao Chen
Department of Chemistry, MIT
External Link (chenmaofudan.wixsite.com)
Managed By
Jon Gilbert
MIT Technology Licensing Officer
Patent Protection

Heterogeneous Organic Gel Catalyst for Photo-Controlled Chemistry

Provisional Patent Application Filed
Publications
Logic-Controlled Radical Polymerization with Heat and Light: Multiple-Stimuli Switching of Polymer Chain Growth via a Recyclable, Thermally Responsive Gel Photoredox Catalyst
Journal of the American Chemical Society, Feb 15, 2017, p. 2257-2266

Applications

Radical polymerization is often used in the design and fabrication of new materials for a variety of applications, including but not limited to coatings, adhesives, and gels used in tissue culture and other biological settings.

Problem

The ability to initiate and control radical polymerization using light (photo-CRP) has been a recent topic of great interest in polymer chemistry. In photo-CRP applications, light can be used to activate a suitable photoredox catalyst, which induces a controlled polymerization reaction that can be terminated by shutting off the light. However, to date, nobody has designed a polymerization reaction that is responsive not only to light, but simultaneously to other types of stimuli such as heat. Furthermore, readily recyclable photoredox catalysts are limited in scope. This type of multi-stimuli-responsive CRP, which integrates different environmental cues to produce unique polymers, could lead to the production of a much more diverse array of polymers.

Technology

This invention involves an organic photocatalyst called 10-phenylphenothiazine (PTH), which is conjugated to a thermally responsive gel to create Gel-PTH in a simple three-step synthesis. When Gel-PTH is swollen in a monomer-containing solution, it provides a transparent framework through which initiators and monomers can diffuse into and begin polymerizing via photo-CRP and heat-responsive reactions. When the Gel-PTH is removed from the solution, when the temperature is increased, or when the light is turned off, the polymerization reaction is effectively turned off. In this way, polymerization is controlled by three separate stimuli—light, heat, and presence of the photocatalyst. The Inventors tested Gel-PTH catalysis using three different types of trithiocarbonate (TTC) initiators and seven different types of monomers—NIPAAM ((4-nitrophenyl)-phenothiazine), DMA (dimethylacrylamide), nBA (n-butyl acrylate), MA (methyl acrylate), EGMEA (ethylene glycol methyl ether acrylate), HEA (2-hydroxyethyl acrylate), and IBA (isobutyl acrylate.) They were able to create at least 17 polymers with molar masses, ranging from 14.8 kDa to 46.6 kDa, by adjusting the molar ratios of the monomer, initiator, and PTH, by using different solvents, and by increasing or decreasing the time of the reaction. Furthermore, the inventors demonstrated that the Gel-PTH catalyst could be easily recycled and re-used in multiple polymerization reactions with no loss of efficiency.

Advantages

  • Simple three-step synthesis of Gel-phenothiazine (PTH)
  • Robust switching of photo-CRP reactions in response to temperature, light, and catalyst presence
  • Wide range of monomers including acrylates, methacrylates, acrylamides, vinyl esters and vinyl amides
  • New opportunities for stimuli-responsive controlled polymerization