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The MIT Technology Licenses Office welcomes companies to get to know us personally. We find it most effective to work individually with a company to identify specific areas of interest. We then bring inventions, which specifically match the company's interests to the attention of the company. With 500 new invention disclosures coming into our office each year, our portfolio is constantly changing. The technologies highlighted here do not encompass our entire portfolio. We therefore encourage companies to keep in touch on a regular basis and also to contact us when a particular technology need arises.
Our technology is usually early stage and often requires substantial development by the licensing company before a commercial product is ready for market. Because of this, we often find that the best contact person from the company is one who is knowledgeable about the company's science and technology and also familiar with the long-term strategic plans of the company.
8172 – This technology has applications in automated CNC milling and machining, specifically to enable universally automated machining using different work pieces. CNC milling and machining often deals with rough cut work pieces of different sizes and shapes. Fixturing, or the process of 'holding' the work piece in a manner that allows it to be machined effectively, is difficult to... Read More
17412 – Hyperspectral imaging (HSI) combines spatial images and spectral signatures for non-destructive, real-time material analysis and identification. Conventional HSI is either performed by scanning systems or snapshot systems. While scanning systems suffer from low optical signal throughput, snapshot systems have poor spatial resolution and low signal-to-noise ratio. This technology... Read More
16512 – (–)-Agelastatin alkaloids are a family of natural-occurring alkaloids with potent anticancer activity. The inventors have developed a method of concise synthesis of all six known (–)-agelastatin alkaloids as well as nine advanced synthetic intermediates that may induce apoptotic cell death across a wide range of cancer types. This technology may be used in treatment of a wide range... Read More
16016 – Epipolythiodiketopiperzine (ETP) alkaloids are a highly complex class of natural products with potent anticancer activity. The inventors have developed a method of flexible and scalable synthesis to allow the constructions of dozens of ETP derivatives that may induce apoptotic cell death across a wide range of cancer types. This technology may be used in treatment of a wide range of... Read More
15852 – Drug delivery via collagen-mediated second harmonic generation (SHG) is of interest to both pharmaceutical and cosmetic companies seeking a system by which to develop or improve spatiotemporally controlled, photoreactive delivery of compounds to a variety of tissues. Additionally, collagen-mediated SHG can be utilized for the imaging of fine tissue structures at single-cell resolution. ... Read More
15506 – Degradation of the nucleic acid backbone has been a concern for therapeutic applications such as gene therapy and siRNA. The resistance of nucleic acids to degradation in plasma and other environments can be enhanced through the process of phosphorothiation that replaces the non-binding oxygen in the sugar-phosphate backbone of a DNA with sulfur to create a phosphorothioate... Read More
15365 – Monitoring environmental pollution, detection of biomarkers in biological samples and tracking food pathogens require simultaneous identification of multiple of analytes. In developing markets, low cost robust assays of adequate sensitivity and specificity are not available. This work presents a compact point-of-care sensor platform capable of simultaneous detection of multiple... Read More
17878 – This technology can be used in making the logic element for information processing in: Data centers consume almost 1.3 percent of the world's total electricity output. As the number of data centers grows, this ratio is expected to grow. The primary energy cost is due to digital circuitry and computational elements. Conventionally, the digital element comprising CMOS transistors uses... Read More
17835 – This technology can be used for quality control and assurance in the supply chain for different process industries including: In-process quality control in a processing industry is critical for meeting standards of the finished product, reducing waste, and optimizing the process flow. For example, in a dairy supply chain, quantification of constituents in milk is important at an early... Read More
16392 – This tool has applications towards designing adhesives for fully hydrated conditions, such as for suturing wounds inside the body. Most common synthetic adhesives are not effective when they are applied to a wet surface. Thus, less convenient alternatives must be substituted in certain contexts. For example, wounds inside the body must be closed with sutures, even though an adhesive... Read More