Point of care
detection of HIV and other infectious diseases, which require multiplexed
separation and isolation of antibodies
separation and isolation of cells
purification in a column
This is a device for isolating individual antibodies, proteins or cells from a complex mixture, and it addresses the current technology's inefficiencies.
Multiplexed isolation of rare antibodies, proteins or cells from complex mixtures is a process essential for disease diagnosis and drug development. However, current methods, such as affinity chromatography and flow cytometry, can be time and labor intensive when used for interrogating more than a single protein in a sample, and are not well-suited for detecting rare events due to their relatively low throughput. Professor Jay Han and colleagues have developed a novel method to isolate rare proteins and cells in complex biological samples by flowing a sample incubated with antibody-coated beads of different sizes in a spiral microfluidic channel. The device takes advantage of the principles of inertial microfluidics to separate the differently sized beads, each bound to a different protein of interest, with high fidelity and throughput. This system has a variety of applications, ranging from sample purification in pharmaceutical contexts to point of care disease diagnosis, and can be easily adapted for multiplexing.
that can be used for research, industrial and clinical purposes
Can work with
small or large volume sample
Sample can be
easily analyzed with downstream tools